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<!DOCTYPE knimeNode PUBLIC "-//UNIKN//DTD KNIME Node 2.0//EN" "http://www.knime.org/Node.dtd">
<knimeNode icon="generic_node.png" type="Manipulator">
    <name>TMTAnalyzer</name>
    
    <shortDescription>
        Calculates TMT quantitative values for peptides
    </shortDescription>
    
    <fullDescription>
        <intro><p>Calculates TMT quantitative values for peptides</p>
		<p>
			<a href="http://ftp.mi.fu-berlin.de/OpenMS/release-documentation/html/TOPP_TMTAnalyzer.html">Web Documentation for TMTAnalyzer</a>
		</p>

        </intro>
        
		<option name="version">Version of the tool that generated this parameters file.</option>
		<option name="log">Name of log file (created only when specified)</option>
		<option name="debug">Sets the debug level</option>
		<option name="threads">Sets the number of threads allowed to be used by the TOPP tool</option>
		<option name="no_progress">Disables progress logging to command line</option>
		<option name="force">Overwrite tool specific checks.</option>
		<option name="id_pool">ID pool file to DocumentID's for all generated output files. Disabled by default. (Set to 'main' to use /group/ag_abi/OpenMS/knime_packaging/OpenMS-Release/share/OpenMS/IDPool/IDPool.txt)</option>
		<option name="test">Enables the test mode (needed for internal use only)</option>
		<option name="select_activation">Operate only on MSn scans where any of its precursors features a certain activation method (usually HCD for iTRAQ). Set to empty string if you want to disable filtering.</option>
		<option name="reporter_mass_shift">Allowed shift (left to right) in Da from the expected position.</option>
		<option name="channel_active">Each channel that was used in the experiment and its description (126-131 for TMT-6-plex) in format &lt;channel&gt;:&lt;name&gt;, e.g. &quot;114:myref&quot;,&quot;115:liver&quot;.</option>
		<option name="isotope_correction">Enable isotope correction (highly recommended). Note that you need to provide a correction matrix (see isotope_correction:tmt-6plex otherwise the tool will fail.</option>
		<option name="do_normalization">Normalize channels? Done by using the Median of Ratios (every channel / Reference). Also the ratio of medians (from any channel and reference) is provided as control measure!</option>
		<option name="channel_reference">Number of the reference channel (126-131).</option>
		<option name="tmt-6plex">Override default values (see Documentation); use the following format: &lt;channel&gt;:&lt;-2Da&gt;/&lt;-1Da&gt;/&lt;+1Da&gt;/&lt;+2Da&gt; ; e.g. '126:0/0.3/4/0' , '128:0.1/0.3/3/0.2'.</option>
		<option name="Program"></option>

    </fullDescription>
    
    <ports>
		<inPort index="0" name="in [mzML]">input raw/picked data file  [mzML]</inPort>
		<outPort index="0" name="out [consensusXML]">output consensusXML file with quantitative information [consensusXML]</outPort>
		<outPort index="1" name="out_mzq [mzq]">Optional output file of MzQuantML. [mzq]</outPort>
		<outPort index="2" name="out_stats [tsv]">output statistics as tab-separated file (readable by R or Excel or ...) [tsv]</outPort>
 </ports>
    <views>
        <view index="0" name="TMTAnalyzer Std Output">The text sent to standard out during the execution of TMTAnalyzer.</view>
        <view index="1" name="TMTAnalyzer Error Output">The text sent to standard error during the execution of TMTAnalyzer. (If it appears in gray, it's the output of a previously failing run which is preserved for your trouble shooting.)</view>
    </views>    
</knimeNode>
